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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
21.21
Human Site:
S590
Identified Species:
35.9
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
S590
L
I
K
E
E
I
L
S
E
N
D
Q
L
S
N
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
S590
L
I
K
E
E
I
L
S
E
N
D
Q
L
S
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
S590
L
I
K
E
E
I
L
S
E
N
D
Q
L
S
N
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
S590
L
I
K
E
E
I
L
S
K
N
D
Q
L
A
N
Rat
Rattus norvegicus
NP_001101888
2143
241191
S590
L
V
R
E
E
I
L
S
K
N
D
Q
L
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
K590
L
V
K
E
E
I
L
K
E
K
K
E
L
L
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
E586
L
D
D
P
R
I
I
E
G
N
P
D
L
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
S599
H
L
T
S
A
L
V
S
G
S
Y
D
T
N
L
Honey Bee
Apis mellifera
XP_393800
2028
231830
G566
L
L
E
L
C
E
V
G
D
D
T
S
V
F
I
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
S254
F
I
E
N
G
I
K
S
P
M
K
S
F
R
Y
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
I239
A
I
S
S
P
G
A
I
K
E
V
F
L
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
V569
S
H
N
V
Q
L
A
V
D
V
V
A
L
S
L
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
I373
I
L
S
L
L
K
K
I
R
L
E
R
Y
E
V
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
V392
L
R
E
K
Q
I
K
V
V
Y
K
S
L
L
V
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
100
N.A.
100
N.A.
86.6
80
N.A.
N.A.
53.3
N.A.
26.6
N.A.
6.6
6.6
20
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
73.3
N.A.
33.3
N.A.
40
46.6
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
15
0
0
0
0
8
0
15
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
0
0
0
15
8
36
15
0
0
8
% D
% Glu:
0
0
22
43
43
8
0
8
29
8
8
8
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
8
8
0
% F
% Gly:
0
0
0
0
8
8
0
8
15
0
0
0
0
0
0
% G
% His:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
43
0
0
0
65
8
15
0
0
0
0
0
0
8
% I
% Lys:
0
0
36
8
0
8
22
8
22
8
22
0
0
8
0
% K
% Leu:
65
22
0
15
8
15
43
0
0
8
0
0
72
15
15
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
0
0
43
0
0
0
8
36
% N
% Pro:
0
0
0
8
8
0
0
0
8
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
15
0
0
0
0
0
0
36
0
0
0
% Q
% Arg:
0
8
8
0
8
0
0
0
8
0
0
8
0
8
0
% R
% Ser:
8
0
15
15
0
0
0
50
0
8
0
22
0
36
8
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
8
0
8
0
0
% T
% Val:
0
15
0
8
0
0
15
15
8
8
15
0
8
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _